Why was lesinurad discontinued?

Why was lesinurad discontinued?

On April 15, 2019, the FDA announced the discontinuation of Ironwood Pharmaceuticals’ Duzallo (lesinurad/allopurinol) and Zurampic (lesinurad). — The discontinuation was due to business reasons and is not due to any safety, efficacy or quality issues.

What is lesinurad used for?

Lesinurad is used in combination with a xanthine oxidase inhibitor to treat hyperuricemia (high levels of uric acid) in people with gout (sudden attacks of redness, swelling, pain, and heat in one or more joints) whose disease is not controlled with their current medication.

Is lesinurad available in the US?

Zurampic (lesinurad) is used to treat gout along with other antigout medications, like allopurinol (Zyloprim) or febuxostat (Uloric). Zurampic (lesinurad) is no longer available in the United States because it’s been discontinued.

How much does lesinurad cost?

Price. A one-month supply of lesinurad costs approximately $394. It is significantly more expensive than probenecid, which costs about $34 for a 30-day supply. In addition, a one-month supply of allopurinol costs about $10.

What is the side effects of lesinurad?

Get medical help right away if you have any of these very serious side effects, including: weakness on one side of the body, sudden vision changes, trouble speaking, confusion, chest/jaw/left arm pain, shortness of breath, unusual sweating. This medication can commonly cause a rash that is usually not serious.

Which is better allopurinol or febuxostat?

Conclusions. Febuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Similar reductions in gout flares and tophus area occurred in all treatment groups.

Is there an alternative to allopurinol?

Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout.

Is probenecid still available?

probenecid (Benemid brand no longer available) Side Effects, Dosage.