What is the protocol for the treatment of anaphylaxis?

What is the protocol for the treatment of anaphylaxis?

Epinephrine (1 mg/ml aqueous solution [1:1000 dilution]) is the first-line treatment for anaphylaxis and should be administered immediately. In adults, administer a 0.3 mg intramuscular dose using a premeasured or prefilled syringe, or an autoinjector, in the mid-outer thigh (through clothing if necessary).

Can you use cardiac EPI for anaphylaxis?

Epinephrine is safe for anaphylaxis when given at the correct dose by intramuscular injection. The majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly dosed.

How does anaphylaxis affect the heart?

During anaphylaxis, coronary hypoperfusion caused by systemic vasodilation, plasma leakage, loss of volume due to increased vascular permeability and reduced venous return can contribute to cardiac output suppression, leading further (33) to myocardial damage and ventricular dysfunction.

What are the five steps given for anaphylaxis action?


  • LAY PERSON FLAT – do NOT allow them to stand or walk.
  • Phone ambulance – 000 (AU) or 111 (NZ)
  • Phone family/emergency contact.
  • Further adrenaline may be given if no response after 5 minutes.
  • Transfer person to hospital for at least 4 hours of observation.

What is the first line treatment for anaphylaxis?

Epinephrine is the first-line treatment for anaphylaxis. Data indicate that antihistamines are overused as the first-line treatment of anaphylaxis. By definition, anaphylaxis has cardiovascular and respiratory manifestations, which require treatment with epinephrine.

Why is epinephrine given for anaphylaxis?

When treating anaphylaxis, epinephrine is generally given via an intramuscular (IM) route. This is well established to be effective and life-saving. One advantage of IM administration is immediate use (without requiring intravenous access), including by patient auto-injection.

Can anaphylaxis cause heart?

Cardiovascular disease (CVD) increases the risk of severe or fatal anaphylaxis, and some medications for CVD treatment can exacerbate anaphylaxis.

Does anaphylaxis cause high heart rate?

Without treatment, more severe, life-threatening anaphylaxis symptoms may occur: Drop in blood pressure, with a weak pulse or confusion. Increased heart rate.

Which 4 of the following are correct signs and symptoms of anaphylaxis include?

Signs and symptoms include:

  • Skin reactions, including hives and itching and flushed or pale skin.
  • Low blood pressure (hypotension)
  • Constriction of the airways and a swollen tongue or throat, which can cause wheezing and trouble breathing.
  • A weak and rapid pulse.
  • Nausea, vomiting or diarrhea.
  • Dizziness or fainting.

Does anaphylaxis cause tachycardia?

Tachycardia is one of the earliest signs of anaphylaxis, usually preceding the hypotension or other symptoms, and sometimes accompanied by the infamous “aura of impending doom”.

What is the most important intervention for the treatment of anaphylaxis?

The most important intervention for the treatment of anaphylactic shock is the use of IM epinephrine. Pediatric dosing for IM epinephrine, using concentration of 1:1,000, is 0.01 mg/kg intramuscular (max dose 0.5 mg).

How to perform cardiopulmonary resuscitation for anaphylaxis?

Anaphylaxis with cardiac or circulatory arrest Cardiopulmonary resuscitation with cardiac massage and aided ventilation in a ratio of 30 :2 must be started (Fig.​Fig.1).1). An automatic defibrillator should be connected. And in case of ventricular fibrillation early defibrillation has to be initiated.

What is the arrest rhythm in anaphylaxis?

Asystole/Pulseless Electrical Activity (PEA) Algorithms. The arrest rhythm in anaphylaxis is often PEA or asystole. See the ACLS Pulseless Arrest Algorithm in Part 7.2: “Management of Cardiac Arrest.”

Are beta-blockers effective in the treatment of severe anaphylaxis?

In patients prescribed beta-blockers for coronary artery disease (CAD), both the medication and the underlying comorbidity complicate the treatment of severe anaphylaxis. The beta-blocker counteracts epinephrine by limiting heart rate and compromising cardiac output.