What is SAM-e 400 mg used for?
For depression, many studies have started patients at 400 to 600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is increased gradually over a few weeks.
Can you get SAM-e as a prescription?
SAM-e has been approved as a prescription drug for depression in Germany, Italy, Spain, and Russia, and has been in use in Europe for over three decades. It is available without a prescription in the United States and some other countries.
What does SAM-e do for the body?
S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. SAMe helps produce and regulate hormones and maintain cell membranes. A synthetic version of SAMe is available as a dietary supplement in the U.S. In some countries in Europe, SAMe is a prescription drug.
How long does it take for SAM-e supplement to work?
“Starting patients with 200 mg 30 minutes before breakfast and 30 minutes before lunch minimizes the overstimulation and insomnia which some patients report in the first few weeks. This can be switched to 400 mg before breakfast after a few weeks.” Patients typically notice improvement in energy within two weeks.
How does SAMe affect the brain?
Objective. S-Adenosylmethionine (SAMe) is a major methyl donor in the brain and is also an antidepressant with few reported side effects; however, SAMe is relatively expensive and unstable. Brain SAMe can be increased by giving methionine to rats, raising the possibility that methionine may be an antidepressant.
Can you take SAMe long term?
Information on the long-term safety of SAMe is limited because the participants in most studies took it only for short periods of time. However, in one study of alcohol-related liver disease, participants took SAMe for 2 years; in that study, no serious side effects were reported.
Is SAMe good for anxiety?
SAMe is used by mouth for depression, anxiety, heart disease, fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, dementia, Alzheimer’s disease, slowing the aging process, chronic fatigue syndrome (CFS), improving mental performance, liver disease, and Parkinson’s disease.
Can SAMe make you sleepy?
Side effects may include dry mouth, nausea, gas, diarrhea, headache, anxiety, a feeling of elation, restlessness, and insomnia. Sweating, dizziness, and palpitations have also been reported. For this reason, you should not take SAMe at night. Large doses of SAMe may cause mania (abnormally elevated mood).
How does SAMe work in the brain?
S-ADENOSYL-l-METHIONINE AS A POTENTIAL ANTIDEPRESSANT. One of the better-studied natural agents is S-adenosyl-l-methionine (SAMe), a major methyl donor in the brain that is involved in the pathways for synthesis of hormones, neurotransmitters, nucleic acids, proteins, and phospholipids (10, 11) (Figures 1 and 2).
Is SAMe good for fatty liver?
While there are currently no medications for NAFLD or NASH, we are testing the effects of S-adenosylmethionine (SAMe). SAMe is a natural compound found in our bodies, and it may play a role in reducing liver inflammation that results from these conditions.
Do you have to wean off SAMe?
Any time you are taking anything for your mood whether it is a prescribed antidepressant or a supplement such as SAMe, you need to taper off from it should you decide to quit taking it.
When should I take SAMe?
SAM-e should be taken on an empty stomach. It can be stimulating, so it’s best to take it early in the day so it doesn’t disrupt your sleep.