What is basiliximab induction?
Basiliximab is a monoclonal antibody that binds to the α-chain of the interleukin (IL)-2 receptor. It is used as induction therapy in kidney transplantation.
When to use basiliximab?
Basiliximab (Simulect) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody that is indicated for the prevention of acute organ rejection in adult and pediatric renal transplant recipients in combination with other immunosuppressive agents.
How does basiliximab work?
Basiliximab is an immunosuppressant drug known as a monoclonal antibody. It works by slowing down your body’s defense system (immune system) to prevent your body from rejecting the new kidney after surgery (acute rejection).
Is basiliximab an immunosuppressant?
Simulect (basiliximab) is an immunosuppressant drug known as a monoclonal antibody used with other medications to prevent organ rejection after a kidney transplant.
What is Simulect used for?
Basiliximab is used to prevent organ rejection in people who have received a kidney transplant. It is usually taken along with other medications (such as cyclosporine, corticosteroids) to allow your new organ to function normally. Basiliximab is an immunosuppressant drug known as a monoclonal antibody.
How is basiliximab administered?
Reconstituted Simulect® should be given either as a bolus injection or diluted to a volume of 25 mL (10 mg vial) or 50 mL (20 mg vial) with normal saline or dextrose 5% and administered as an intravenous infusion over 20 to 30 minutes.
Is basiliximab lymphocyte depleting?
Anti-IL-2R mAb (basiliximab and daclizumab) As these drugs specifically target activated T cells, they do not cause significant lymphocyte depletion and are not associated with major adverse effects when compared to lymphocyte-depleting agents.
Can azathioprine cause skin problems?
Background: Azathioprine (AZA) hypersensitivity syndrome is a rare side effect that typically occurs early in the initiation of therapy and may include a cutaneous eruption. It is often under-recognized because it mimics infection or disease exacerbation.
How is basiliximab made?
Simulect® (basiliximab) is a chimeric (murine/human) monoclonal antibody (IgG1k), produced by recombinant DNA technology, that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2Ra, also known as CD25 antigen) on the surface of activated T-lymphocytes.
Is sirolimus the same as rapamycin?
Sirolimus, also known as rapamycin or by the brand name Rapamune, is a medicine that lowers the body’s natural immunity. The immune system response is thought to be involved in Nephrotic Syndrome. It is also used to prevent rejection of transplanted organs, such as the kidney, heart, and liver.