What does IL-1Ra do?

What does IL-1Ra do?

IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 (IL-1), preventing IL-1 from sending a signal to that cell.

What produces IL-1Ra?

hepatic cells
IL-1Ra is produced by hepatic cells with the characteristics of an acute phase protein. Endogenous IL-1Ra is produced in numerous experimental animal models of disease as well as in human autoimmune and chronic inflammatory diseases.

Is IL-1 an antibody?

IL-1 beta Polyclonal Antibody.

Is IL-1Ra a cytokine?

IL-1 is an extremely potent inflammatory cytokine that is involved in myriad immunological responses, spanning both innate and adaptive immunity (15). Of the cytokines that bind the primary receptor IL-1RI, there are two similar yet distinct molecules, IL-1α and IL-1β, which are encoded by different genes.

Is IL-1RA anti-inflammatory?

The interleukin (IL)-1 family is a group of 11 proinflammatory and anti-inflammatory cytokines.

Where is IL-1RA produced?

IL-1ra is produced by monocytes, macrophages, neutrophils, fibroblasts, epithelial cells, Sertoli cells, microglia.

Is IL-1ra anti-inflammatory?

Where is IL-1ra produced?

What is IL-1 treatment?

Interleukin (IL) 1 is a highly potent proinflammatory mediator that is important in immune defense and in immune-mediated disease. Three pharmacologic inhibitors (sometimes termed blockers) of IL-1 are commercially available: anakinra, canakinumab, and rilonacept (table 1).

How do IL inhibitors work?

Interleukin inhibitors work by targeting cytokines that act as chemical signals between the white blood cells in response to an invading infection. They suppress the activity of these cytokines, thus suppressing the immune system and reducing inflammation.

Is IL-1ra anti inflammatory?

What antibodies are used in flow cytometry for IL-1ra?

Flow Cytometry – Anti-IL-1RA antibody [EPR6483] (ab124962) Flow Cytometry analysis of HeLa cells labelling IL-1RA with purified ab124962 at 1/20 (red). Cells were fixed with 4% paraformaldehyde. An Alexa Fluor ® 488-conjugated goat anti-rabbit IgG (1/500) was used as the secondary antibody.

Does ab124962 bind specifically to IL-1ra?

In Western blot, ab124962 was shown to bind specifically to IL-1RA. A band was observed at 19 kDa in wild-type A431 cell lysates with no signal observed at this size in IL1RN knockout cell line ab273379 (knockout cell lysate ab275530 ). To generate this image, wild-type and IL1RN knockout A431 cell lysates were analysed.

What is the sequence of the synthetic peptide in IL-1ra 150?

Synthetic peptide within Human IL-1RA aa 150 to the C-terminus (C terminal). The exact sequence is proprietary. WB: A431 cell lysates. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies.

What is the difference between interleukin-1 and decoy receptor IL1R2?

Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells.