What are the most common inherited coagulation disorders?

What are the most common inherited coagulation disorders?

Hemophilia A and B are the most frequent inherited bleeding disorders. Together with von Willebrand disease, a defect of primary hemostasis associated with a secondary defect in coagulation factor VIII (FVIII), these X-linked disorders include 95% to 97% of all the inherited deficiencies of coagulation factors.

What is hereditary coagulation disorders?

Hereditary bleeding disorders occur due to the absence or deficiency of specific clotting proteins. The three most common hereditary bleeding disorders are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency) and von Willebrand disease.

Which coagulation factors are inherited?

Deficiencies of coagulation factors that cause a bleeding disorder, other than factor VIII and factor IX, are inherited as autosomal recessive traits and are generally rare, with prevalence in the general population varying between 1 in 500 000 and 1 in 2 000 000.

What is an example of a hereditary coagulopathy?

Hereditary hypocoagulopathy, or hemophilias, are very rare and include Von Willebrand disease (VW factor deficiency or abnormality), Hemophilia A (clotting Factor VIII deficiency) and Hemophilia B (clotting Factor IX deficiency.

What is the most common blood disorder?

Anemias, where there are not enough red blood cells or the cells do not work correctly, are among the most common blood disorders. According to the American Society of Hematology, anemia affects more than 3 million Americans.

What is hereditary factor VIII deficiency?

Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.

How is hemophilia B inherited?

Hemophilia B is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome. If the factor IX gene on one chromosome does not work, the gene on the other chromosome can do the job of making enough factor IX.

What causes coagulation disorder?

Major causes of coagulation disorders resulting in too much clotting include: Factor V Leiden. In this genetic disorder, a blood clotting protein called factor V Leiden overreacts causing the blood to clot too often or too much. Antithrombin III (ATIII) deficiency.

What are hematologic abnormalities?

Hematologic disorders involve the blood and include problems with red blood cells, white blood cells, platelets, bone marrow, lymph nodes, and spleen. Children can experience a variety of disorders, some are genetic while others are acquired.

Are blood disorders genetic?

Overview. Blood disorders are when something in your blood prevents it from doing its job. While some blood disorders are caused by genes, some can develop as a result of other diseases, medications or a lack of nutrients in your diet.