Can you give vancomycin in renal failure?
Vancomycin therapy is widely used in patients with decreased renal function, and serum levels of this agent must be closely monitored in such patients in order to avoid toxicity and subtherapeutic levels, in particular because emergence of resistance to glycopeptide antibiotics has been noted [12].
How do you give vancomycin to dialysis patients?
The first dose of administered vancomycin (Hospira Inc, www.hospira.com) was 20 mg/kg (actual weight) (rounded to the nearest 250 mg) and infused at 1000 mg/hr, timed to end with the dialysis session. Subsequent doses of 1000 mg vancomycin were infused during the last hour of each dialysis session.
When should vancomycin be given during dialysis?
Maintenance doses should be administered according to the plasma trough levels, as determined before the session when the patient is on chronic intermittent haemodialysis, at any time for continuous haemodialysis, and 6 hours after the end of haemodialysis when continuous therapy is stopped and vancomycin treatment is …
Is vancomycin safe for CKD?
Infectious Diseases Society of America guidelines recommend achieving vancomycin trough levels of 10 to 20 μg/mL. Usage of vancomycin in high dosages especially ≥ 4 g/d has led to an increase in the incidence of vancomycin-induced nephrotoxicity, particularly in patients with chronic kidney disease (CKD).
How do you administer vancomycin IV?
Vancomycin injection comes as a powder to be added to fluid and injected intravenously (into a vein). It is usually infused (injected slowly) over a period of at least 60 minutes once every 6 or 12 hours, but may be given every 8 hours in newborn babies.
Can vancomycin be dialyzed?
In addition, many dialysis centers administer vancomycin during dialysis, but the dose prescribed may not take intradialytic drug loss into consideration and, thus, may be subtherapeutic because approximately 20%–40% of a vancomycin dose infused during dialysis is subject to dialytic removal (2).
What does vancomycin do to creatinine?
A standardized definition was proposed in the 2009 vancomycin consensus review, which defined vancomycin-induced nephrotoxicity as a minimum of two increases in serum creatinine of at least 0.5 mg/dL or a 50% or greater increase in the serum creatinine from baseline after several days of vancomycin therapy (4).
How do you give vancomycin injection?
How often is vancomycin dosed?
Typically 15 to 20 mg/kg every 8 to 12 hours for most patients (based on actual body weight, rounded to the nearest 250 mg increment). In general, the approach to establishing the vancomycin dose/interval is guided by a nomogram.