Can B cells develop without IL 7?

Can B cells develop without IL 7?

In this study, we clarified that B cell development is arrested at the pre–pro-B cell stage in the absence of IL-7R signaling. We investigated the role of IL-7R in expression of B cell–specific factors at this developmental stage. We found a direct connection between IL-7R signaling and up-regulation of EBF expression.

What produces il12?

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol.

Do NK cells express il7r?

Natural killer (NK) cells are similar to ILC1s but are not considered part of the helper ILC subset and generally do not express the IL-7Rα (45). However, some tissue NK cells express a range of IL-7Rα levels, like in the thymus, colon, and small intestine lamina propria (siLP) (46, 47).

Where is IL-7 produced?

Cells producing IL-7 have been found within the spleen, LN, liver, lung, skin and intestine (15–20). Although specific adherent cell types such as the fibroblastic reticular cells (FRCs) of LNs have been identified as IL-7 source cells (16), many cellular sources remain incompletely characterized.

What does IL-7 do to T cells?

Cytokines IL-7 and IL-15 are essentially involved in T-cell homeostasis. IL-7 is required for developing mature T cells in the thymus, whereas in the periphery, it promotes the survival of naïve and memory T cells by upregulating the antiapoptotic molecule Bcl-2.

What does IL-7 do in B cell development?

Interleukin-7 (IL-7) plays several important roles during B cell development including aiding in; the specification and commitment of cells to the B lineage, the proliferation and survival of B cell progenitors; and maturation during the pro-B to pre-B cell transition.

Which cytokine is responsible for early development of B cells in bone marrow?

TSLP is a cytokine that has stimulatory effects on B cells under in vitro culture conditions and plays a role in early B cell development [47]. Generally, only developing B cells respond to IL-7 signaling [48].

What does IL-12 stimulate?

IL-12, a disulfide-linked heterodimer composed of a p40 and p35 subunit, has been identified as an immune cell stimulator that promotes differentiation and proliferation of T cells and enhances the production of interferon gamma.

What are the signaling pathways activated upon binding to IL-7?

The signaling pathways activated upon IL-7 binding to the receptor complex are JAK-STAT, PI-3 kinase and Src kinase pathways. JAK3, a protein tyrosine kinase is constitutively associated with the carboxy-terminal region of the gamma chain. Studies in mice lacking JAK3 have shown that it is required for transducing γc dependent signals.

What receptors are involved in the gamma chain of the IL-7?

The gamma chain is also shared by IL-2, IL-4, IL-9, IL-15 and IL-21 receptors. The signaling pathways activated upon IL-7 binding to the receptor complex are JAK-STAT, PI-3 kinase and Src kinase pathways. JAK3, a protein tyrosine kinase is constitutively associated with the carboxy-terminal region of the gamma chain.

What is the function of IL-7R?

IL-7 receptor (IL-7R), binding to its cognate ligand IL-7 (interleukin 7), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. IL-7 (interleukin 7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes.

What is the function of Interleukin 7?

Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. …